Closed-loop controlled administration of propofol using bispectral analysis.
case_series · Level IV
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- Record sourced from PubMed, PMID 9797518.
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Abstract
Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed-loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporating target-controlled infusion technology combined with a pharmacokinetic-dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.
Medical subject headings
- Anesthesia, Spinal
- Anesthetics, Intravenous
- Drug Delivery Systems
- Electroencephalography
- Propofol