The effect of lamotrigine on naloxone-precipitated opiate withdrawal.
rct · Level II
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Abstract
We hypothesized that lamotrigine, a putative glutamate release antagonist, would attenuate glutamate-mediated signs of opiate withdrawal. Seven heroin-dependent subjects were hospitalized, stabilized on oral levorphanol 6 mg three times daily, and thrice underwent withdrawal precipitated by naloxone 0.4 mg intravenously. Lamotrigine (placebo, 250 mg, and 500 mg) was randomly given as a pretreatment 6 h before naloxone. Lamotrigine did not significantly attenuate any measure of opiate withdrawal. Lamotrigine was well-tolerated in subjects, although one did develop an allergic rash.
Medical subject headings
- Analgesics
- Heroin Dependence
- Naloxone
- Narcotic Antagonists
- Substance Withdrawal Syndrome
- Triazines