Effects of a low concentration of isoflurane on contrast sensitivity in volunteers.

Taylor, S R; Khan, O A; Swart, M L; Lockwood, G G; Jones, J G · Br J Anaesth · 1998

case_series · Level IV

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Abstract

The effects of 0.15% quasi steady-state end-tidal isoflurane on the contrast sensitivity of five healthy volunteers were investigated by measuring their performance in computer generated letter discrimination tasks. A series of letters were displayed on a computer screen so that the luminance of the letter differed from that of the background. Two protocols were used: in the static protocol, the letter remained displayed on the screen until the subject responded, whereas in the dynamic protocol, the letter was displayed for 1/72 s only. Isoflurane significantly decreased contrast sensitivity in both protocols in all subjects.

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