dMi-2, a hunchback-interacting protein that functions in polycomb repression.
basic_science · Level V
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Abstract
Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.
Medical subject headings
- Adenosine Triphosphatases
- Autoantigens
- Carrier Proteins
- DNA-Binding Proteins
- Drosophila Proteins
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Insect Proteins
- Transcription Factors