The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 9839827.
- Also identified by DOI 10.1016/S0304-3959(98)00132-8.
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Abstract
In a double blind, placebo controlled trial of 40 volunteers, the burning discomfort associated with application of capsaicin cream (0.025%) was compared to placebo, GTN cream (1.33%) and to the combination of capsaicin cream (0.025%) plus GTN cream 1.33%. Median VAS for burning pain were 0 for the placebo, GTN and GTN + capsaicin groups and 3 for the capsaicin group after single application of each cream at daily intervals. This study demonstrates that after single application the addition of GTN to capsaicin significantly reduces the burning discomfort associated with application of capsaicin alone.
Medical subject headings
- Capsaicin
- Nitroglycerin
- Pain
- Vasodilator Agents