The antibody catalysis route to the total synthesis of epothilones.
basic_science · Level V
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- Record sourced from PubMed, PMID 9843936.
- Also identified by PMC identifier 24496.
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Abstract
An efficient monoclonal aldolase antibody that proceeds by an enamine mechanism was generated by reactive immunization. Here, this catalyst has been used in the total synthesis of epothilones A (1) and C (3). The starting materials for the synthesis of these molecules have been obtained by using antibody-catalyzed aldol and retro-aldol reactions. These precursors were then converted to epothilones A (1) and C (3) to complete the total synthesis.
Medical subject headings
- Antibodies, Catalytic
- Epothilones
- Epoxy Compounds
- Fructose-Bisphosphate Aldolase
- Thiazoles