A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 9853620.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The ability to produce monoclonal antibodies (Mabs) in plants offers the opportunity for the development of an inexpensive method of mucosal immunoprotection against sexually transmitted diseases. To investigate the suitability of plant-expressed Mabs for vaginal preventive applications, we compared a humanized anti-herpes simplex virus 2 (HSV-2) Mab expressed in mammalian cell culture with the same antibody expressed in soybean. We found these Mabs to be similar in their stability in human semen and cervical mucus over 24 h, their ability to diffuse in human cervical mucus, and their efficacy for prevention of vaginal HSV-2 infection in the mouse.
Medical subject headings
- Antibodies, Monoclonal
- Herpes Genitalis
- Plants, Genetically Modified
- Vagina