Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 9855543.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the alpha-synuclein gene. None of the familial cases of PD carried a mutation within the alpha-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the alpha-synuclein gene. We conclude that variation within the alpha-synuclein gene does not play a significant role in the risk for PD in our sample.
Medical subject headings
- Chromosomes, Human, Pair 4
- Nerve Tissue Proteins
- Parkinson Disease
- Point Mutation