p53-independent role of MDM2 in TGF-beta1 resistance.
basic_science · Level V
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- Record sourced from PubMed, PMID 9856953.
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Abstract
Transforming growth factor-beta (TGF-beta) inhibits cell proliferation, and acquisition of TGF-beta resistance has been linked to tumorigenesis. A genetic screen was performed to identify complementary DNAs that abrogated TGF-beta sensitivity in mink lung epithelial cells. Ectopic expression of murine double minute 2 rescued TGF-beta-induced growth arrest in a p53-independent manner by interference with retinoblastoma susceptibility gene product (Rb)/E2F function. In human breast tumor cells, increased MDM2 expression levels correlated with TGF-beta resistance. Thus, MDM2 may confer TGF-beta resistance in a subset of tumors and may promote tumorigenesis by interference with two independent tumor suppressors, p53 and Rb.
Medical subject headings
- Carrier Proteins
- Cell Cycle Proteins
- Cell Division
- DNA-Binding Proteins
- Nuclear Proteins
- Proto-Oncogene Proteins
- Transforming Growth Factor beta
- Tumor Suppressor Protein p53