The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.
case_control · Level III
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- Record sourced from PubMed, PMID 9863603.
- Also identified by PMC identifier 1051518.
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Abstract
Previous work has shown an association between the K variant of the butyrylcholinesterase (BCHE) gene and Alzheimer's disease (AD) in patients carrying the epsilon4 allele of ApoE. We attempted to replicate this finding in 181 UK white AD cases and 71 controls. No difference was found in BCHE-K genotypes (p=0.75) or alleles (p=0.70) between patients and controls. Moreover, despite a significant excess of ApoE epsilon4 in patients versus controls (p<0.0001), we found no evidence to support previous reports of an interaction between ApoE and BCHE-K (chi2=1.49, df=4, p=0.83).
Medical subject headings
- Alzheimer Disease
- Butyrylcholinesterase
- Genetic Variation