Changes in the concentration of insulin-like growth factor I and transforming growth factor beta1 in rat femoral bone during growth.
basic_science · Level V
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Abstract
Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-beta) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGF-beta in all compartments of the femoral bone. The association between IGF-I and TGF-beta is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-beta play an important role in the growth-associated accumulation of bone mass.
Medical subject headings
- Aging
- Bone Density
- Femur
- Insulin-Like Growth Factor I
- Transforming Growth Factor beta