Controlling charge states of large ions.
basic_science · Level V
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- Record sourced from PubMed, PMID 9880246.
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Abstract
The charge state of ions produced in electrospray ionization (ESI) was reduced in a controlled manner to yield predominantly singly charged species by exposure of the aerosol to a bipolar ionizing gas. Analysis of the resulting ions on an orthogonal time-of-flight mass spectrometer yielded mass spectra greatly simplified compared with conventional ESI spectra. The decreased spectral complexity afforded by the charge reduction facilitates the analysis of mixtures by ESI mass spectrometry.
Medical subject headings
- Ions
- Mass Spectrometry
- Oligonucleotides
- Proteins