CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.
basic_science · Level V
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Abstract
Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4(+) helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4(+), natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.
Medical subject headings
- Antigens, CD1
- Antigens, Protozoan
- Glycosylphosphatidylinositols
- Immunoglobulin G
- T-Lymphocyte Subsets
- T-Lymphocytes, Helper-Inducer