The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.
case_control · Level III
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Abstract
In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean +/- SEM difference between these variables was 2.4 +/- 0.3 mmol/L (P =.0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.
Medical subject headings
- Acidosis, Lactic
- Lactates
- Pyruvate Dehydrogenase Complex Deficiency Disease