A cluster of microvillous inclusion disease in the Navajo population.
case_report · Level V
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- Record sourced from PubMed, PMID 9880458.
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Abstract
We report 4 unrelated patients with characteristic microscopic findings of microvillous inclusion disease (MID) with early-onset phenotype. All 4 patients came from the Navajo reservation in northern Arizona. A literature search revealed a fifth unrelated Navajo child with MID. The unusually high incidence in this population indicates that a founder effect might be responsible for an increased frequency of this rare genetic disorder in the Navajo. It is recommended that all Navajo infants presenting with severe diarrhea during early infancy undergo investigation for MID.
Medical subject headings
- Cytomegalovirus Infections
- Indians, North American