Regulation of renin secretion by angiotensin II-AT1 receptors.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 9892157.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Angiotensin II (AngII) resulting as the end product of a proteolytic cascade initiated by renin inhibits the secretion of renin in the sense of a negative feedback. A direct effect of AngII on renal juxtaglomerular epithelioid cells as the main source of renin secretion is mediated via AngII-AT1 receptors and involves calcium-dependent reactions. These reactions may comprise activation of protein kinase C and activation of chloride channels.
Medical subject headings
- Juxtaglomerular Apparatus
- Receptors, Angiotensin
- Renin