Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury.
basic_science · Level V
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Abstract
Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.
Medical subject headings
- Adenosine Diphosphate
- Nitrates
- Poly(ADP-ribose) Polymerases
- Spinal Cord Injuries