Pregnancy enhances the sensitivity of glomerular ecto-adenosine triphosphate-diphosphohydrolase to products of activated polymorphonuclear leukocytes.
basic_science · Level V
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Abstract
To test the hypothesis that pregnancy enhances the sensitivity of glomerular ecto-adenosine triphosphate-diphosphohydrolase to products of activated polymorphonuclear leukocytes, cryostat-cut kidney sections of pregnant and cycling rats were exposed to activated polymorphonuclear leukocytes and subsequently stained for ecto-adenosine triphosphate-diphosphohydrolase activity. The results show that the levels of ecto-adenosine triphosphate-diphosphohydrolase activity of pregnant rats showed a significantly greater decrease after incubation with activated polymorphonuclear leukocytes than did those of cycling rats.
Medical subject headings
- Adenosine Triphosphatases
- Apyrase
- Kidney Glomerulus
- Neutrophils
- Pregnancy, Animal