Three-dimensional dosimetry using polymer gel and magnetic resonance imaging applied to the verification of conformal radiation therapy in head-and-neck cancer.

Abstract

It was our aim to investigate NMR-based BANG gel dosimetry as a three-dimensional dosimetry technique in conformal radiotherapy. The BANG gel consisting of gelatin, water and co-monomers was first validated in a cylindrical glass flask for a single standard beam. Next, the gel contained in a human neck-shaped cast was used to verify a treatment plan for the conformal irradiation of a concave tumour in the lower neck. Magnetic resonance relaxation rate images were acquired and, based on an appropriate calibration of the gel, converted to absorbed dose distributions. The resulting maps were compared with dose distributions measured using radiographic film. The gel-measured dose profiles of standard beams agreed within 3% (root mean square difference) with the profiles measured with high spatial resolution by a diamond detector. For the multi-beam conformal treatment, the difference map between gel-measured and film-measured dose distributions revealed a noise component and a more systematic deviation including structural or space-coherent patterns. The mean absolute value of the difference amounted to 8%. A number of possible causes for this deviation are designated. Polymer gel dosimetry in combination with magnetic resonance imaging is a promising method for dosimetric verification of conformal radiotherapy.