The breast cancer prevention trial (P-1 study). The role of tamoxifen in preventing breast cancer.
review · Level V
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Abstract
The recently completed Breast Cancer Prevention Trial found that tamoxifen can reduce the incidence of breast cancer by nearly half in women at high risk, but the benefit comes at a price of increased risk of endometrial cancer and thromboembolism. This article reviews the actions of tamoxifen and the design, findings, and implications of this study.