Improvement of myelopathy in Sjögren's syndrome with chlorambucil and prednisone therapy.
case_report · Level V
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- Record sourced from PubMed, PMID 9932962.
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Abstract
The authors present a patient with Sjögren's syndrome with a fluctuating and then progressive myelopathic syndrome, and optic nerve involvement. Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided. Spinal MRI showed multiple, extensive intraparenchymal areas of abnormal T2-weighted signal intensity, gadolinium enhancement, and cord swelling, which also improved during the period of treatment.
Medical subject headings
- Chlorambucil
- Glucocorticoids
- Muscular Atrophy, Spinal
- Prednisone
- Sjogren's Syndrome