Bilateral optic neuropathy with IgGkappa multiple myeloma improved after myeloablative chemotherapy.
case_report · Level V
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Abstract
A 49-year-old woman with immunoglobulin GK multiple myeloma developed progressive visual loss with bilateral upper and lower central arcuate scotomas. Funduscopic and electrophysiologic studies indicated bilateral optic neuropathy. The immunoglobulin G fraction of the patient's serum reacted with retinal ganglionic cells in bovine retina. The visual abnormalities remitted after myeloablative chemotherapy and disappearance of the paraprotein.
Medical subject headings
- Functional Laterality
- Immunoglobulin G
- Immunoglobulin kappa-Chains
- Multiple Myeloma
- Myeloablative Agonists
- Optic Nerve Diseases