Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters.
basic_science · Level V
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- Record sourced from PubMed, PMID 9990058.
- Also identified by PMC identifier 15506.
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Abstract
Help for the induction of cytolytic T lymphocytes is mediated by dendritic cells (DC) that are conditioned by CD40 signaling. We identified tumor necrosis factor family member CD27L/CD70, which is expressed by cytolytic T lymphocytes on interaction with DC to control CD154 (CD40L) up-regulation on CD45RA+ helper T cells for subsequent DC stimulation. The results show that the initiation of a cytolytic immune response is determined by regulatory circuits, requiring simultaneous activation and differentiation of all cells involved in T lymphocyte-DC cluster formation.
Medical subject headings
- Antigens, CD
- CD40 Antigens
- Dendritic Cells
- Membrane Proteins
- T-Lymphocyte Subsets
- T-Lymphocytes, Cytotoxic